Standardized Versus Naturalized: An Evaluation of Child Morphological and Syntactic Assessments

Speech-language pathologists may choose to evaluate children’s language using standardized or naturalized assessments. This study investigated if the Clinical Evaluation of Language Fundamentals-Preschool 2 (CELF-P 2), a standardized assessment, and language sampling, a naturalized assessment, reveal the same information about children’s linguistic competence and performance. Children ages 3.0-7.0 were assessed with specific focus on morphology and syntax. The participants completed four morphosyntactic-based subtests of the CELF-P 2. Additionally, play-based interactions, used to elicit natural language, were video-recorded. The CELF-P 2 was scored and language samples were transcribed and analyzed. Mean length of utterance (MLU) scores showed a slightly more variable trend around the mean than CELF-P 2 scores and there were no significant correlations between the two assessments. Furthermore, the two forms of assessment produced incongruous age equivalents for 66% of the participants (four out of six) and participants produced different morphosyntactic structures during each type of assessment. Thus, results indicated limitations and successes of the different assessment approaches. When used alone, either form of assessment did not provide a completely accurate representation of children’s language acquisition. However, when used in conjunction, the two assessments may represent the linguistic competence and performance of children more accurately

Standardized Versus Naturalized: An Evaluation of Child Morphological and Syntactic Assessments

Speech-language pathologists may choose to evaluate children’s language using standardized or naturalized assessments. This study investigated if the Clinical Evaluation of Language Fundamentals-Preschool 2 (CELF-P 2), a standardized assessment, and language sampling, a naturalized assessment, reveal the same information about children’s linguistic competence and performance. Children ages 3.0-7.0 were assessed with specific focus on morphology and syntax. The participants completed four morphosyntactic-based subtests of the CELF-P 2. Additionally, play-based interactions, used to elicit natural language, were video-recorded. The CELF-P 2 was scored and language samples were transcribed and analyzed. Mean length of utterance (MLU) scores showed a slightly more variable trend around the mean than CELF-P 2 scores and there were no significant correlations between the two assessments. Furthermore, the two forms of assessment produced incongruous age equivalents for 66% of the participants (four out of six) and participants produced different morphosyntactic structures during each type of assessment. Thus, results indicated limitations and successes of the different assessment approaches. When used alone, either form of assessment did not provide a completely accurate representation of children’s language acquisition. However, when used in conjunction, the two assessments may represent the linguistic competence and performance of children more accurately.Faculty Sponsor: Dr. Dorothy Leone, Ph.D., CCC-SL

Children's Perception of Conversational and Clear American-English Vowels in Noise

A handful of studies have examined children's perception of clear speech in the presence of background noise. Although accurate vowel perception is important for listeners' comprehension, no study has focused on whether vowels uttered in clear speech aid intelligibility for children listeners. In the present study, American-English (AE) speaking children repeated the AE vowels /ε, æ, ɑ, ʌ/ in the nonsense word /gəbVpə/ in phrases produced in conversational and clear speech by two female AE-speaking adults. The recordings of the adults' speech were presented at a signal-to-noise ratio (SNR) of -6 dB to 15 AE-speaking children (ages 5.0-8.5) in an examination of whether the accuracy of AE school-age children's vowel identification in noise is more accurate when utterances are produced in clear speech than in conversational speech. Effects of the particular vowel uttered and talker effects were also examined. Clear speech vowels were repeated significantly more accurately (87%) than conversational speech vowels (59%), suggesting that clear speech aids children's vowel identification. Results varied as a function of the talker and particular vowel uttered. Child listeners repeated one talker's vowels more accurately than the other's and front vowels more accurately than central and back vowels. The findings support the use of clear speech for enhancing adult-to-child communication in AE, particularly in noisy environments

Children's perception of conversational and clear American-English vowels in noise

Purpose: Much of a child’s day is spent listening to speech in the presence of background noise. Although accurate vowel perception is important for listeners’ accurate speech perception and comprehension, little is known about children’s vowel perception in noise. “Clear speech” is a speech style frequently used by talkers in the presence of noise. This study investigated children’s identification of vowels in nonsense words in noise and examined whether adults’ use of clear speech would result in the children’s more accurate vowel identification. Method: Two female American-English (AE) speaking adults were recorded producing the nonsense word /gəbVpə/ with AE vowels /ɛ-æ-ɑ-ʌ/ in phrases in conversational and clear speech. These utterances were presented to 15 AE-speaking children (ages 5.0-8.5) at a signal-to-noise ratio of -6 dB. The children repeated the utterances. Results: Clear speech vowels were repeated significantly more accurately (87%) than conversational speech vowels (59%), suggesting that clear speech aids children’s vowel identification. Children repeated one talker’s vowels more accurately than the other’s, and front vowels more accurately than central and back vowels. Conclusions: The findings support the use of clear speech for enhancing adult-to-child communication in AE in noisy environments

Vowel Intelligibility in Children With and Without Dysarthria: An Exploratory Study

Children with dysarthria due to cerebral palsy (CP) present with decreased vowel space area and reduced word intelligibility. Although a robust relationship exists between vowel space and word intelligibility, little is known about the intelligibility of vowels in this population. This exploratory study investigated the intelligibility of American-English vowels produced by children with dysarthria and typically-developing children (TD). Three CP and five TD repeated words with contrastive vowels /i-ɪ/,/æ-ɛ/,/ɑ-ʌ/,/o-u/ produced by a native American-English adult. Adult listeners transcribed the utterances orthographically and rated their ease of understanding. Overall, CP presented with less-intelligible vowels than TD. For CP, a trend was found with the lowest intelligibility for /ɑ/ (CP=7%,TD=66%), /ɪ/ (CP=30%,TD=82%), and /ʌ/ (CP=38%,TD=99%), and more heterogeneous vowel confusions; however, intelligibility differences between vowels did not reach statistical significance. Clinical implications include that, unless further studies show vowel-specific effects, treatment targeting the entire vowel system may be warranted for increasing intelligibility

Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo.

BACKGROUND Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune diseases. METHODS To identify generalized vitiligo susceptibility loci, we conducted a genomewide association study. We genotyped 579,146 single-nucleotide polymorphisms (SNPs) in 1514 patients with generalized vitiligo who were of European-derived white (CEU) ancestry and compared the genotypes with publicly available control genotypes from 2813 CEU persons. We then tested 50 SNPs in two replication sets, one comprising 677 independent CEU patients and 1106 CEU controls and the other comprising 183 CEU simplex trios with generalized vitiligo and 332 CEU multiplex families. RESULTS We detected significant associations between generalized vitiligo and SNPs at several loci previously associated with other autoimmune diseases. These included genes encoding major-histocompatibility-complex class I molecules (P=9.05×10−23) and class II molecules (P=4.50×10−34), PTPN22 (P=1.31×10−7), LPP (P=1.01×10−11), IL2RA (P=2.78×10−9), UBASH3A (P=1.26×10−9), and C1QTNF6 (P=2.21×10−16). We also detected associations between generalized vitiligo and SNPs in two additional immune-related loci, RERE (P=7.07×10−15) and GZMB (P=3.44×10−8), and in a locus containing TYR (P=1.60×10−18), encoding tyrosinase. CONCLUSIONS We observed associations between generalized vitiligo and markers implicating multiple genes, some associated with other autoimmune diseases and one (TYR) that may mediate target-cell specificity and indicate a mutually exclusive relationship between susceptibility to vitiligo and susceptibility to melanoma

Common variants in FOXP1 are associated with generalized vitiligo

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 × 10−8) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 × 10−7)

Trends in the perceived body size of adolescent males and females in Scotland, 1990–2014: changing associations with mental well-being

Objectives: This paper explores trends in Scottish adolescents’ body size perceptions and associated mental well-being outcomes. Methods: Data were collected on Scottish 11, 13 and 15-year olds by the Health Behaviour in School-aged Children study between 1990 and 2014 (n=42,312). Logistic regression was used to examine changes in the prevalence of over- and underweight perceptions. Ordinal and linear regression was used to examine changes in the association between body perception and mental well-being. Results: Little change was observed in over- or under-weight perceptions between 1990 and 2014. However, relative to those perceiving their body as ‘about right’, those perceiving themselves as overweight reported decreasing confidence (all groups), decreasing happiness (11- and 13-year old girls) and increasing psychological symptoms (all girls and 15 year-old boys). Perceived underweight is associated with poor well-being, especially in males, but we present little evidence that this is a recent phenomenon. Conclusions: We present evidence suggesting that the influence of body image on adolescent mental health is increasing over time. This may play a role in the recently observed worsening of mental well-being in Scottish adolescents.Publisher PDFPeer reviewe

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Comprehensive association analysis of candidate genes for generalized vitiligo supports XBP1, FOXP3, and TSLP

We previously carried out a genome-wide association study of generalized vitiligo (GV) in non-Hispanic whites, identifying 13 confirmed susceptibility loci. In this study, we re-analyzed the genome-wide data set (comprising 1,392 cases and 2,629 controls) to specifically test association of all 33 GV candidate genes that have previously been suggested for GV, followed by meta-analysis incorporating both current and previously published data. We detected association of three of the candidate genes tested: TSLP (rs764916, P3.0E-04, odds ratio (OR)1.60; meta-P for rs38069333.1E-03), XBP1 (rs6005863, P3.6E-04, OR1.17; meta-P for rs22695779.5E-09), and FOXP3 (rs11798415, P5.8E-04, OR1.19). Association of GV with CTLA4 (rs12992492, P5.9E-05, OR1.20; meta-P for rs2317751.0E-04) seems to be secondary to epidemiological association with other concomitant autoimmune diseases. Within the major histocompatibility complex (MHC), at 6p21.33, association with TAP1-PSMB8 (rs3819721, P5.2E-06) seems to derive from linkage disequilibrium with major primary signals in the MHC class I and class II regions